A Brazilian study has shown that administering a high dose of vitamin D on moderate-to-severe COVID-19 patients does not have beneficial effects on them.
The study, published in the Journal of the American Medical Association, included 240 hospitalised patients with COVID-19 who were moderate-to-severely ill at the time of enrollment from June 2, 2020, to August 27, 2020.
The researchers, led by a Sao Paulo rheumatologist, Igor Murai, divided the patients into two equal groups at random and ensured that the patients received treatment with standard COVID-19 protocols that included antibiotics and anti-inflammatory medications.
Among hospitalised patients with COVID-19, a single high dose of vitamin D3, compared with placebo, did not significantly reduce hospital length of stay and the findings did not support the use of a high dose of vitamin D3 for treatment of moderate-to-severe COVID-19.
According to the researchers, Vitamin D appears to regulate both innate and adaptive immune responses.
Furthermore, a small non randomised trial demonstrated that administration of regular boluses of vitamin D3 before the infection was associated with better survival and less severe disease among older frail patients with COVID-19.
“However, in the current trial, a single dose of 20,000 IU of vitamin D3 did not result in any clinically relevant effects among hospitalised patients with moderate-to-severe COVID-19, contesting the use of supplementary vitamin D3 as a treatment for patients with this disease,” they noted.
Commenting, A professor of virology, Oyewale Tomori, said that Vitamin D is an immune booster and it’s not specifically indicated for COVID-19.
“Vitamin D boosts immunity and it is not only vaccines that can boost the immunity.
“There are other things you will add, like vitamins and good food, to boost the immune system and vitamins is not specifically for COVID-19 management.
“Vitamins are good for the body and it helps the body cells and the ability to defend the body,” Tomori said.
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