A simplified COVID-19 testing protocol can detect minimal quantities of the SARS-CoV-2 using samples from the nose and throat as well as saliva and may be useful in testing patients with low viral titers such as asymptomatic patients or testing individuals prior to quarantine release. The high sensitivity method can be used in laboratories with minimal molecular biology equipment and expertise, and enables several patient samples to be pooled, decreasing the number of tests required for larger populations.