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Study in mice shows genes may be altered through drug repurposing

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December 17, 2020
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Researchers screened drugs that can enhance the PAX6 gene and found MEK inhibitors can stimulate PAX6 expression in the eye. They tested this drug in newborn PAX6 deficient mice and found that either topical or oral administration of the drug enhanced PAX6 and partially normalized their eye development. Mice treated with topical MEK inhibitor had clearer corneas (less scarring) and could see better.

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